Comments on: Breaking Down Carbonyl Reaction Mechanisms: Reactions of Anionic Nucleophiles (Part 2) https://www.masterorganicchemistry.com/2010/04/28/breaking-down-carbonyl-reaction-mechanisms-reactions-of-anionic-nucleophiles-part-2/ Sat, 30 Mar 2024 11:43:13 +0000 hourly 1 https://wordpress.org/?v=6.6.2 By: Almaan Ahmed Hadwani https://www.masterorganicchemistry.com/2010/04/28/breaking-down-carbonyl-reaction-mechanisms-reactions-of-anionic-nucleophiles-part-2/#comment-689181 Sat, 30 Mar 2024 11:43:13 +0000 http://masterorganicchemistry.wordpress.com/?p=302#comment-689181 you really dont know how much this site helps self studying students again another perfect explination

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By: harsh https://www.masterorganicchemistry.com/2010/04/28/breaking-down-carbonyl-reaction-mechanisms-reactions-of-anionic-nucleophiles-part-2/#comment-585137 Fri, 18 Sep 2020 10:19:23 +0000 http://masterorganicchemistry.wordpress.com/?p=302#comment-585137 well, right now i m in class 12 preparing for iit and whatever stuff u give…..really develops a love (a bond) with ORGANIC chemistry…thank you for all this work…….thanking from the depth of my heart

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By: Thomas Luedeke https://www.masterorganicchemistry.com/2010/04/28/breaking-down-carbonyl-reaction-mechanisms-reactions-of-anionic-nucleophiles-part-2/#comment-405703 Tue, 16 Jun 2015 05:14:42 +0000 http://masterorganicchemistry.wordpress.com/?p=302#comment-405703 I absolutely loathe the way conjugate addition is taught, think it is one of the very worst handled parts of organic chemistry. I’m taking the ACS National Organic Test, and they *love*, **love**, ***love*** conjugate addition, including enone.

I’ve read the pertinent sections in three or four of the major organic texts, and they all fail disastrously. They fling around useless terms like “strong” or “weak” bases, don’t provide any guidance on the criteria for achieving kinetic or thermodynamic products as major and/or in what proportions, then leave you to hang when it comes to solving problems. I’m absolutely livid.

This is about the best description I’ve seen, although I’m still confused. It seems like unless you’re laying on some serious heat (like a Wittig or a Grignard reagent) onto a conjugated enone, you might as well fall back on 1,4-addition products as being major?? I wouldn’t characterize methoxide as a “weak” base (try dropping a beaker down your shorts and tell me it is “weak”), but apparently it is in terms of conjugate addition…..

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