Comments on: LiAlH[Ot-Bu]3 For The Reduction of Acid Halides To Aldehydes

By: James Ashenhurst

James Ashenhurst — Tue, 23 Apr 2024 16:21:35 +0000

In reply to Dániel Budai. Fixed - thank you!

By: Dániel Budai

Dániel Budai — Tue, 23 Apr 2024 06:48:42 +0000

Hi James, there’s a typo in the beginning of the article:

“Acid halides can also be reduced to acid halides using Pd-C / barium carbonate with hydrogen, otherwise known as Rosenmund’s catalyst”

I assume the second “acid halides” should be “aldehydes” :)

By: chandru

chandru — Fri, 01 Mar 2024 01:16:11 +0000

hey james what is the neccesity to install such bulky groups ?

By: Cuando el ácido 2,3-dimetilhexanoico se trata con SOCl2 / piridina, seguido de LiAl [OC (CH3) 3] 3H, ¿cuál sería el producto? Gracias – ElbuhoSabio

Thu, 01 Oct 2020 17:08:59 +0000

[…] el gran compuesto de aluminio (tri-litiotert-butoxialuminio hidruroCh. 20 Química Orgánica, Paula Yurkanis Bruice) con los grupos donadores de electrones permite que […]

By: Quando l’acido 2,3-dimetilesanoico viene trattato con SOCl2 / piridina, seguito da LiAl [OC (CH3) 3] 3H, quale sarebbe il prodotto ???? Grazie – GufoSaggio

Fri, 27 Dec 2019 11:38:30 +0000

[…] il grande composto di alluminio (litio tri-terz-idruro di alluminio e butossialuminio, Cap. 20, Chimica organica, Paula Yurkanis Bruice) con i gruppi donatori di elettroni consente al […]

By: James Ashenhurst

James Ashenhurst — Sat, 26 Oct 2019 01:03:12 +0000

In reply to Dakota. It will deprotonate them but not add, that's about it.

By: Dakota

Dakota — Thu, 24 Oct 2019 20:46:17 +0000

Does LTBA react with carboxylic acids?

By: Chris G.

Chris G. — Sun, 25 Mar 2018 22:50:29 +0000

What happens if you add LAH to an acyl chloride? Would the acyl chloride reduce to an alcohol or would no reaction occur?

By: Michael

Michael — Wed, 05 Apr 2017 00:55:08 +0000

Would it be possible to use DIBAL-H instead of Li(O-t-Bu)3?

By: James

James — Mon, 02 Feb 2015 22:17:20 +0000

In reply to ben. Yes! On a personal note I have tried both the in situ prep and buying it from Aldrich and had better luck with the store-bought reagent.