The Robinson Annulation
Description: The Robinson annulation is a method for forming six membered rings. It is a sequential combination of the Michael reaction and the Aldol condensation.
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Real-Life Examples:
Org. Synth. 1961, 41, 38
DOI Link: 10.15227/orgsyn.041.0038
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MOC Quiz ID 1798
Is there a missing methyl group for the B-carbon to the carbonyl?
Thanks!
Yes – you’re right. Thanks for the spot. Fixed!!!
What if we need to synthesis five membered ring instead of six member. What type of base will preferrably help.
Robinson annulation is not going to help in that case.