SN2 of Cyanide with Alkyl Halides to give Nitriles
Description: Alkyl halides (or tosylates) will react with cyanide ion to give alkyl cyanides (nitriles) in an SN2 reaction.
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Real-Life Examples:
Org. Synth. 1922, 2, 9
DOI link: 10.15227/orgsyn.002.0009
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Org. Synth. 1928, 8, 52
DOI link: 10.15227/orgsyn.008.0052
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Org. Synth. 1925, 5, 103
DOI link: 10.15227/orgsyn.005.0103
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Org. Synth. 1936, 16, 35
DOI link: 10.15227/orgsyn.016.0035
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Org. Synth. 1938, 18, 50
DOI link: 10.15227/orgsyn.018.0050
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Org. Synth. 1943, 23, 33
DOI link: 10.15227/orgsyn.023.0033
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What if you add CH2CN to the reaction as well? Instead of just CN?
Do you mean CH3CN ? Acetonitrile? That’s a polar aprotic solvent, should be a great solvent for a reaction like this.
Hi,
The first example reaction is for acetal formation…not alkyl halides for nitriles. Other than that, this is fantastic! Finally understand reactions properly! :)
the work is good, i real like it.