SN2 reaction of amines with alkyl chlorides to give ammonium salts
Description: Amines will react with alkyl halides to give ammonium salts. Importantly, this occurs even if only one equivalent of the alkyl halide and amine are used.
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Real-Life Examples:
Org. Synth. 1928, 8, 38
DOI Link:10.15227/orgsyn.008.0038
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Org. Synth. 1932, 12, 40
DOI Link:10.15227/orgsyn.012.0040
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Org. Synth. 1932, 12, 40
DOI Link: 10.15227/orgsyn.012.0040
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Org. Synth. 1939, 19, 61
DOI Link: 10.15227/orgsyn.019.0061
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Org. Synth. 1938, 18, 56
DOI Link: 10.15227/orgsyn.018.0056
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Hi,
is it possible to eliminate the quaternary ammonium ion?
Yes, that’s the Hofmann elimination. https://www.masterorganicchemistry.com/2017/10/18/the-hofmann-elimination/
Hi, in Description is written “+ salt”. What kind of salt is created? I suppose that there is 2 HX? Thx, P.
The “salt” is the ammonium salts that form during deprotonation of the amine.