Formation of Grignard Reagents from Alkyl Halides
Description: Treatment of alkyl halides with magnesium metal leads to formation of a Grignard reagent.
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Real-Life Examples
DOI Link: 10.15227/orgsyn.006.0054
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Org. Synth. 1930, 10, 4
DOI Link: 10.15227/orgsyn.010.0004
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Org. Synth. 1931, 11, 66
DOI Link: 10.15227/orgsyn.011.0066
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Org. Synth. 1932, 12, 48
DOI Link: 10.15227/orgsyn.012.0048
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Org. Synth. 1931, 11, 80
DOI Link: 10.15227/orgsyn.011.0080
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Org. Synth. 1931, 11, 84
DOI Link: 10.15227/orgsyn.011.0084
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Org. Synth. 1947, 27, 65
DOI Link: 10.15227/orgsyn.027.0065
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I don’t think I can view the image properly. The arrow pushing looks incorrect. But that’s okay. My book can finish this up, thank you.
OK. I agree that the image is blurrier than I’d like.
Would I be correct in stating that the Grignard reagent is so basic, with such a high pKa (approx. 50) that it is able to de-protonate any hydrogen with a lower pKa? Additionally, that in a synthesis it will de-protonate the most acidic hydrogen?