Alkylation of enamines with alkyl halides
Description: Enamines are nucleophiles, and will react with alkyl halides to give alkylation products. Subsequent treatment with aqueous acid will give ketones.
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Real-Life Example
Org. Synth. 1961, 41, 76
DOI Link: 10.15227/orgsyn.041.0076
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tes: Acid can assist the reaction, making it faster in two ways. First, it makes the carbonyl more reactive for step 2, and it also allows for
？？where is the carbonyl?
Here, we’re talking about formation of the imine from the aldehyde or ketone.
Just found this to be extremely concise, yet simple. Very thorough and very appreciative. THANK YOU I am doing medicinal and synthetic organic chem, amongst some other units, so such a thorough site like this will be advantageous.
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B
Glad you’re finding it useful Bruce.